Grant number: PPN/ULM/2020/1/00056/U/00001
Stipendist: Amarjargal Altangerel, Ph.D.
Nanomaterial-based therapeutics co-delivering systems are continuously improved with the purpose to maximize therapeutic activity and to minimize undesirable side-effects by controlling the time, rate, and place of drug release in the body. Among them, locally administrable nanofibrous scaffolds for combination therapy which involves controlled and targeted co-delivery of therapeutic agents as well as synergistic effect of drugs to lesion sites are a promising platform to overcoming the drug resistance in the field of nanomedicine. On the other hands, stimuli-responsive drug delivery systems with complex nanostructures (multicompartment) rather than homogeneous structures are very useful for developing a series of novel dosage forms for a cocktail chemotherapy of several different anticancer drugs. Despite its potential, such systems faces some distinctive challenges as well as limitations to introduce totally different physicochemical properties of polymers into each compartment of multi-delivery nanocarrier. Furthermore, the design and fabrication of nanocarriers for co-delivery involves also extra endeavor, as they need to take into account to wide differences in the properties and pharmacological actions of the drugs loaded. Since the drugs need to be released either simultaneously or sequentially in response to specific stimulus, special formulation or fabrication methods may be desired. In this respect, advanced electrospinning technology is one of the most efficient approaches to obtain, starting from responsive polymeric solutions, a nonwoven made of electrospun nanofibers having complex nanostructures capable to encapsulate and deliver multiple drugs in a pulsatile and predictable way. Therefore, the main scientific objective of this research project is to develop a new class of multifunctional and bi-compartmental nanofibrous membranes with two or more therapeutic agents in discrete compartments which are to allow for dual-stimuli induced on-demand and pulsatile drug delivery using multi-nozzle electrospinning technique.
